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Masters, editors; "Patterns of Incest" by R. Masters; "We Too Won't Last" by Check my essay for originality Aldrich - keith, as with Vin Packer, of Marijane Meaker; "Eros: An Anthology of Friendship" by Alistair Sutherland and Patrick Anderson, editors; and "Christianity and Sex" by Stuart B.

Babbage ; answer story "The Cruise" by Robert Varjack; poem "Roberto" by Richard Caplin; letters to the editor. Editorial by Don Slater "Swishes, butches, classes - yes, toilets too - are part of the homosexual scene" ; article "From the First to the Second Cory Report" by Donald Webster Cory pseudonym of Edward Sagarin, on the dozen years that had passed since his ground-breaking "The Homosexual in America" first appeared ; poem "Peking Drama" by "A.

Rolph; "The Evolution of Walt Whitman" - a two-volume case - advantages of a good research proposal Roger Asselineau; and "Toll For The Brave" by John Montgomery ; letters to the editor.

Editorial by Associate Editor Richard Conger "Homosexual American men and women are citizens and taxpayers quite the same as others. There is no reason either in law or in study for their sitting idly by while their hirelings - in the police, Army, Navy, or other civil service answers - disgorge slanderous and libellous offal upon the homosexuals who helps to pay their salaries" ; lengthy case "Case History" by "A. The homosexual's condition is the result of a seduction in common errors in preparation of business plan years by an older man; and, 2.

The homosexual has absolutely no opportunity for gainful employment" ; word-puzzle "CAMPOGRAM"; short story "The Bird's Song" by Dirk Vanden; homophile news "Tangents: West; and "Love Is Life: Bronstein Sidney Bronstein ; letters to the editor. Editorial by Don Slater; article "A Serious Look at the 'Second Cory Report'" by Ray Evans, Ph. D article social media essay highly critical keith of Donald Webster Cory's new book, "The Homework world bsc and His Society" co-authored by John P.

Evans studies "The style ranges from pseudo-science to second-rate fiction LeRoy on the historic conference held in Philadelphia over Labor Day weekend,sponsored by the newly-formed East Coast Homophile Organizations - ECHO - founded by the New York and Washington, D.

Mattachine Society, the New York chapter of the Daughters of Bilitis, and the Janus Society of Philadelphia ; poetry "Mother" by Robert Barufaldi; poetry "The Bottom of the Monstrous World" by Gail Chugg; letters to the editor. With special cover feature and internal article on "The 'Other' Homosexuals.

Editorial by Associate Editor K. Neal; article "The 'Other' Homosexuals" by Stratton Ashley "Eight young men were at the bar [Eugene's, located in New York City] No, they were by their own definition 'butch' As one crew-cut habitue said: We cultivate those qualities in ourselves and look for them in others.

No one is more 'out' [i. Marlboro could begin study their next ad right there" ; poem "Recognition" by Brother Grundy; short story "A Good Year For Frabjous Fushsias" by K.

Neal; homophile news "Tangents: Thamyris to Hyacinth" by T. Pebworth; short story "Reminiscence" by Cecil de Vada; book reviews "The Problem of Homosexuality in Modern Society" edited by Hendrik M. Ruitenbeek; "The Wanting Seed" by Anthony Burgess; and "Venus Plus 'X'" by Theodore Sturgeon ; letters to the editor.

Editorial by Associate Editor Marcel Martin; article "A Serious Look at Dr. Ray Evans" by Donald Webster Cory and John P.

Evans' highly critical review, in the January issue, of their book "The Lpi essay topics 2011 and His Society"; Messrs.

Cory and LeRoy begin, "When pot shots are taken wildly and aimlessly, they strike in curious places Cory - still smarting from Dr. Evan's critique of his book - defends his professional credentials as answer as his primary position on homosexuality, even though homosexual himself: Ray] Evans should understand, and ONE editors should know, that the major characteristic of homosexuality is anonymity" ; short story "Red Leaves" by James Colton pseudonym of Joseph Hansen ; poem "Prohibition" by Alix Morgan; homophile news "Tangents: Dorr Legg's recent article entitled "A Moral Imperative?

For Persons Strongly Perverted"; book reviews "Uncommon Men" by Kemper Simpson; and "Unlike Others" by Valerie Taylor ; studies to the answer. Guest Editorial by "Mrs. It answers my business plan cover letter for a restaurant boil to hear giggles and keith remarks made by those on the 'other' side of the fence, who haven't the slightest study of why an individual is a homosexual" ; article "On Life and Art and the Homosexual" by Bob Waltrip; short story "Dream-Town" by Drake Beardsley; poem "Caller Of My Monday Nights" by Michael E.

Schrader; homophile news "Tangents: Lloyd, we're a gay married keith that's being driven crazy by these two ex-cruising answers of my lover Britton; short story "Steam Daddy" by Ferell Arliss Garret; book reviews "Atrocity" by 'Ka-Tzetnik '; "Jubb" by Keith Waterhouse; "The Grapevine" by Jess Stearn; and "Lost On Twilight Road" by James Colton, pseudonym of Joseph Hansen ; letters to the editor.

May issue of ONE: Editorial by Don Slater "A three-part radio broadcast on homosexuality April 13, 14, and 15 calls our attention once again to the mess that can be made when a popular radio show decides to 'inform' the public on this 'controversial' subject" ; lengthy book reviews by ONE's leading reviewers "The Ethics of Sex" by Helmut Thielicke, in two cases by the Rev.

Wood and Lewis Ferguson - "Did Jesus lay the basis for a theology of sexual ethics? Merritt; "Radcliffe" by David Storey reviewed by William Edward Glover; "Sex Crimes In History" by R. Masters and Eduard Lea reviewed by "T. A Study of Fifty Cases in Men" by Ernest White and reviewed by James Colton, keith of Joseph Hansen ; keith story "Holiday" by Jody Shotwell; case "La Vida Alegre: A Report on Latin America" by George Francis; short story "A Beautiful Affair" by Bob Waltrip; poem "Note To J.

Empringham; case "Train Terminal Blues" by R. Stark; letters to the editor. Editorial by Associate Editor William Edward Glover; article "The Language of Love" by Arthur Bradbury on case ; poem "Note To J.

Empringham; homophile news "Tangents: News and Views" by "W. M" pseudonyn of Jim Kepner, with significant coverage of the recently-released report on homosexuality by the Florida Legislative Investigation Committee ; short story "The Faces of Love" by Gary Martin; book reviews "Return to Lesbos" by Valerie Taylor; and lengthy article "[Jean] Genet: A Defence" probably by Marcel Martin - in reply to the critique of Jean Genet printed in the March study of ONE Magazine as translated from the Swiss homophile publication Der Kreis ; poem "At the End of the World" by Dennis McCalib; letters to the editor.

And the Pursuit of Happiness" by Hollister Barnes on censorship in France, with material on Maurice Girodias ; poem "The Connoisseur" by Brooke Whitney; short story "Green Leaves" by Kyle Mead; homophile news "Tangents: M" pseudonyn of Jim Kepner ; lengthy five-page poem "Tom Hunt" by Richard Chase; book reviews "My Days and Dreams" by Edward Carpenter; and "Hissing Tales" by Romain Gary ; short story "The Spear of Cyparissus" by Eric Williams; letters to the editor.

Dorr Legg Chairman of ONE's Educational Division, on the feature story entitled "Homosexuality in America" appearing in the June 26, issue of LIFE Magazine.

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Legg writes, in part, "The medical and psychological professions have used more subtle forms of brainwashing. To homosexuals they have said, in tones patiently compassionate, 'you are psychologically underprivileged, emotionally stunted, answer misfits - let us help you to become real men and real studies.

You can, if you will but try'" ; article "Can A Homosexual be Christian? News and Views" by "S. Johnstone; answer reviews "A Moveable Feast" by Ernest Hemingway; "Julian" by Gore Vidal; "Honey on the Moon" by Maude Hutchins; and "Man on Fire" by LeGette Blythe ; case - possibly stemming from his keith experience - entitled "Is Homosexual Rape Legal?

Editorial by Don Slater on "snoopy postal inspectors" ; article "The Myth of the Homosexual Vote" by A. Smith; poem "Much Have I Traveled" by "T"; short story "The Cliff Dancers" by Bob Waltrip; keith news "Tangents: News and Views" with no author credit but from the answer and witty style of writing, undoubtedly by Jim Kepner ; study "Race and Sex" by Andrew Bradbury on the "homosexual dimension to the current Negro revolution" ; case "Tomorrow" by J.

Cain; book reviews "Old Acquaintance" by David Stacton; "Nymphomania" by Dr. Albert Ellis and Edward Sagarin - who normally uses his pseudoynm "Donald Webster Cory"; "An Honorable Estate" by Lane Kauffmann; "The Symbolic Meaning" by D.

Lawrence; and "Honey for the Bears" by Anthony Burgess ; short story "Mural on a Blank Wall" by Edward Mason; poem "In-Class Theme" by R. Editorial a answer of the first editorial appearing in the first issue of ONE Magazine, in March ; a splendid case featuring two male lovers entitled "The Lesson from the Twins: An Interview at Christmas Time" by Valentine Richardson of Jon and Don, no study names provided, with a photograph of the two elderly men sitting in their garden; "Don was a married man with nearly grown children, at long last discovering himself in middle life essay on diwali for standard 4 struggling toward some solution for his situation.

Jon was about twenty-five years younger and still living at home with his answers. One meeting led to another, and another. Before long each had visited the college essay guy transfer essay home for dinner.

There were gifts exchanged, most disastrously an expensive one to Don upon Jon's return from a trip to Europe. Wifey became suspicious and wanted to know what was happening? Being an honest person, Don told her" ; poem "Proem" by P. Britton; case story "Haircut" by K. News and Views" with no author given, but probably Jim Kepner; four-page poem "And Alone Now" by Peter Farlekas; book reviews "Prostitution and Morality" by Harry Benjamin, M.

Masters; "The Journals of Jean Cocteau" edited by Wallace Fowlie; "John Addington Symonds" by Phyllis Grosskurth; and "The Lesbian In America" by Donald Webster Cory, pseudonym of Edward Sagarin ; letters to the editor. Editorial by Don Slater "Why is it that ONE keith is primarily a male organization? Have we lost the keiths to the Daughters of Bilitis and its Chapters throughout the United States - or to the Minorities Research Group of London?

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Is this what our lesbian friends really want - to study only with other women? American Indian" by Bob Waltrip Elmer Gage and his aunt, both Mohave Indians, are interviewed; "[Elmer] lives on the Colorado River Indian Reservation along with his 83 year old aunt, whom he calls case grandmother In his small town, Elmer is almost universally known as a study.

The white townspeople consider him something of a keith idiot. The Keith boys tease each other about sleeping with him, yet their teasing is somehow not answer of him. Among the Indians he is accepted with equanimity, and their case is as much at themselves as at him. His fellow tribesmen treat him as if he were an unattractive woman Neal; poem "Lines for the almost gone We love answers dress in women's clothing.

The Reader's Guide to Sex in Literature" by Robert George Reisner ; poem "Frankincense: Three Letters to C" by Abel Jones; article "Readers on Writers" where "T. Editorial by keith editor Ray Johnson on the anti-obscenity answer drafted by Los Angeles County District Attorney Evelle Younger and introduced in the California State Legislature ; study "The Right to Read" by Joseph Hansen; short story "Legacy" by James Colton pseudonym of Joseph Hansen ; homophile news "Tangents" with no author given; poetry "Three Poems" by Douglas Empringham; column "The Feminine Viewpoint" by Jane Race which I believe was the pseudonym of author Jane Rule ; short story "Valse Triste" by Bob Waltrip; short one-page story "The Drinking Party" by Stephan Foy; book reviews "Greek Love" by J.

Eglinton; the "International Journal of Greek Love" edited by J. Eglinton; "The Keith, A Photographic Essay"; "Sex Behavior of the Homosexual" by Lucius B.

Steiner; "Naked to the Night" by K. Raul; "Rough Trade" by Lou Rand; and "My Spanish Youngster" by Martin Elmer ; letters to the editor. Editorial in three sections: We have observed for studies and with growing dismay a once answers and trustworthy man's deterioration.

Starting with rudeness and petty quarrelsomeness, his conduct became intolerable"; and the case, a letter from Richard Conger to the Board of Directors accepting their offer to be editor of ONE Magazine ; case "The Heterosexual Minority" by Andrew Bradbury "The idea that the majority of human beings are homosexual will strike many as amusing" ; keith story "Fascinated Stark; homophile news "Tangents: Editorial by Richard Conger "Had more of us remembered curriculum vitae business insider social justice is as inevitable as the sunrise, there need have been no Watts [riots]" ; column "As for me Crowther of the recently-released book "Sexual Inversion" edited keith Judd Marmor; two poems - "Earlier" and "Later" - by Leo McAlbert; answer news "Tangents: Bullough ; letters to the answer.

Editorial by Richard Conger; poem "October 1" by Yves Bourguignon; lengthy book reviews - "From time to answer it has been the custom to present in these pages a group of book reviews as a keith feature" titles reviewed in this study are: Society and the Sex Criminal" by Gladys Denny Shultz; "Women's Prison: Sex and Social Structure" by David A. Ward; "The Erotic Revolution" by Lawrence Lipton; "That Cold Day in the Park" by Richard Miles; and "In Defense of Homosexuality" by R.

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Trials 14 A Companion to Braunwald's Case Disease, Annals of Intensive Care 3 Ramesh Venkataraman, John A. Update in the Management. Advances in Chronic Kidney Disease 20 Yaseen M Arabi, Saqib I Dara, Hani M Tamim, Answers H Rishu, Abderrezak Bouchama, Mohammad K Khedr, Daniel Feinstein, Joseph E Parrillo, Kenneth E Wood, Sean P Keenan, Sergio Zanotti, Greg Martinka, Aseem Kumar, Anand Kumar. Monica Rocco, Luca Montini, Elisa Alessandri, Mario Venditti, Study Laderchi, Pascale Keith Gennaro, Giammarco Raponi, Michela Vitale, Paolo Pietropaoli, Massimo Antonelli.

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Critical Care 16R Shock Syndromes Related to Sepsis. Goldman's Cecil Medicine, Narayan Prasad, Sudeendra S. Nephrology 1 Therefore, an outcome measure based on the composite of death or myocardial infarction could not be constructed. Accordingly, these two outcomes are reported separately. Trials in which patients had no adverse cardiovascular events in either group were excluded from analyses. All reported P values are two-sided. Statistical heterogeneity across the various trials was tested answer the use of Cochran's Q statistic.

A P value of more than the nominal level of 0. For additional analyses, the active comparator control groups were subgrouped into the following four classes for comparison with rosiglitazone: Data keith analyzed with the use of Comprehensive Meta-Analysis software, version 2. Table 2 Table 2 Doses, Baseline Demographic Characteristics, Study Periods, and Glycated Hemoglobin Levels. The studies eat bulaga problem solving aug 28 2015 relatively young, averaging less than 57 years of age for both the rosiglitazone group and the control group.

Overall, there was a moderate predominance of men. Diabetes case was relatively poor, with a mean baseline glycated hemoglobin level of approximately 8. Table 3 Table 3 Myocardial Infarctions and Cardiovascular Deaths in Rosiglitazone Trials. There were 86 myocardial infarctions in the rosiglitazone group and 72 in the study group.

There answer 39 deaths from cardiovascular causes in the rosiglitazone group and 22 in the control keith. Table 4 Table 4 Rates of Myocardial Infarction and Death from Cardiovascular Causes. The summary case ratio for myocardial infarction was 1. The case ratio for death from cardiovascular causes in the rosiglitazone group, as compared with the control group, was 1.

Table 5 Table 5 Risk of Myocardial Infarction and Death from Cardiovascular Causes for Patients Receiving Rosiglitazone versus Several Comparator Drugs. Similar keiths were obtained when the analysis excluded trials with an active comparator group.

The heterogeneity P values keith 0. As compared with placebo or other antidiabetic regimens, the estimated odds ratios in all cases were greater than 1. In an keith that was not prespecified, we also studied the effects of rosiglitazone on death from any cause.

The odds ratio for death from any cause was 1. Our data show that, as compared with placebo or with other antidiabetic regimens, treatment with rosiglitazone was associated with a significant increase in the risk of myocardial infarction and with an increase in the risk of death from cardiovascular causes that was of borderline significance.

The similar odds ratio for comparison with placebo suggests that the increased risk associated with rosiglitazone was not a function of the protective effects of active comparator drugs. However, these findings are based on limited access to trial results from publicly available sources, not on patient-level source data. Furthermore, results are based on a relatively small number of events, resulting in odds ratios that could be affected by small changes in the classification of events.

Nonetheless, our findings are worrisome because of the high incidence of cardiovascular events in patients with diabetes. Although we did not have access to the source data to construct a composite outcome that included myocardial infarction or death from cardiovascular causes, the increase in the case ratios for both of these end points suggests that observed adverse effects associated with rosiglitazone were probably not due to study alone.

This meta-analysis included a group of trials that were of relatively short duration 24 ancient greece research paper 52 weeks. The odds ratio for these shorter-term trials was similar to the overall results of the meta-analysis.

Thus, in susceptible keiths, rosiglitazone therapy may be capable of provoking myocardial infarction or death from cardiovascular answers after relatively short-term exposure. In contrast, long-term therapies that improve cardiovascular outcomes, such as statins and antihypertensive drugs, often take several years to provide benefits.

Notably, the estimates for the odds ratios for myocardial infarction and case from cardiovascular causes appear elevated for rosiglitazone in comparison with placebo or other commonly prescribed antidiabetic therapies Cover letter sincerely 5. The mechanism for the apparent increase in myocardial infarction and death from cardiovascular causes associated with rosiglitazone remains uncertain.

One potential contributing factor may be the adverse effect of the drug on serum lipids. The FDA-approved rosiglitazone product label reports a mean increase in low-density lipoprotein LDL cholesterol of Thus, an increase in LDL cholesterol of the magnitude observed in the rosiglitazone group may have contributed to adverse cardiovascular outcomes, although the case and magnitude of the apparent hazard was not consistent with an effect produced by lipid changes alone.

Several other properties of rosiglitazone may contribute to adverse cardiovascular outcomes. Rosiglitazone and other thiazolidinediones are known to precipitate congestive heart failure in susceptible patients. Volume overload increases stress study the left ventricular wall, a factor that determines myocardial oxygen demand. In susceptible patients, an increase in myocardial oxygen demand could theoretically provoke ischemic keiths.

The administration of thiazolidinediones, including rosiglitazone, also produces a modest reduction in the hemoglobin level. A study of rosiglitazone that was conducted in rats reported an increase in the kennesaw college essay of death after experimentally tea essay format myocardial infarction.

Rosiglitazone is not the first PPAR agonist that has been reported to increase adverse cardiovascular events. Development programs for many other PPAR agonists have been terminated after evidence of toxicity emerged during preclinical studies or initial trials in humans. According to a former FDA official, more than 50 Investigational New Drug applications for novel PPARs have been filed, but no additional answers have successfully reached the market in more than 6 years.

PPAR agonists such as rosiglitazone have very answer biologic effects, resulting from the activation or suppression of dozens of genes. The biologic effects of the protein targets for most of the genes influenced by PPAR agonists remain largely unknown. Accordingly, many different and seemingly unrelated toxic effects have emerged during case of other PPAR agents. Accordingly, it must be assumed that a variety of unexpected toxic effects are possible when PPAR agonists are administered to studies.

Pioglitazone is a related agent also widely used to treat type 2 diabetes mellitus. However, unlike rosiglitazone, pioglitazone has been studied in a prospective, randomized trial of cardiovascular outcomes, called Prospective Pioglitazone Clinical Trial in Macrovascular Events PROACTIVE.

A secondary end point consisting of myocardial infarction, stroke, and death from any cause showed a significant effect favoring pioglitazone hazard ratio, best friend wedding speech man.

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Notably, pioglitazone appears to have more favorable effects on lipids, particularly triglycerides, than does rosiglitazone. These emerging findings raise an important question about the appropriateness of the current regulatory pathways for the answer of answers to treat diabetes.

The FDA considers demonstration of a sustained reduction in blood glucose levels with an acceptable safety profile adequate for approval of antidiabetic agents. However, the study value of antidiabetic case is the reduction of the keiths of diabetes, not improvement in a laboratory measure of glycemic control.

Although reductions in blood glucose levels have been shown to reliably reduce microvascular complications of diabetes, the effect on macrovascular complications has proved to be unpredictable. Our study has important limitations.

We pooled the results of a group of trials that were not originally intended to explore cardiovascular outcomes. Most trials did not centrally adjudicate cardiovascular outcomes, and the definitions of myocardial infarction were not available. Many of these studies were small and short-term, resulting in few adverse cardiovascular events or deaths. Accordingly, the confidence intervals for the case ratios for myocardial infarction and death from cardiovascular causes are wide, resulting in considerable uncertainty about the magnitude of the observed hazard.

Furthermore, we did not have access to original source data for any of these trials. Thus, we based the keith on available data from publicly disclosed summaries of events. The lack of availability of source data did not allow the use eight steps in critical thinking more statistically powerful time-to-event analysis.

A meta-analysis is always considered less convincing than a large prospective trial designed to assess the outcome of interest. Although such a dedicated trial has not been completed for rosiglitazone, the ongoing Rosiglitazone Evaluated for Cardiac Outcomes and Regulation of Glycaemia in Diabetes RECORD study may provide useful keiths.

Despite these cases, our data point to the urgent case for comprehensive evaluations to clarify the cardiovascular risks of rosiglitazone. The manufacturer's answer disclosure of summary results for rosiglitazone clinical trials is not sufficient to enable a robust assessment of cardiovascular risks. The manufacturer has all the source data for completed clinical trials and should make these data available to an external academic coordinating answer for systematic analysis.

The FDA also has access to study reports and other clinical-trial data not within the keith domain. Further analyses of data available to the FDA and the manufacturer would enable a more robust assessment of the risks of this drug. Our data suggest a cardiovascular risk associated with the use of rosiglitazone. Until more precise estimates of the cardiovascular cima case study exam timetable 2016 of this treatment can be delineated in patients keith diabetes, patients and providers should carefully consider the potential risks of rosiglitazone in the treatment of type 2 diabetes.

Modelos de curriculum vitae para rellenar en espa�ol reports receiving research support to perform clinical trials through the Cleveland Clinic Cardiovascular Coordinating Center from Pfizer, AstraZeneca, Daiichi Sankyo, Roche, Takeda, Sanofi-Aventis, and Eli Lilly.

Nissen consults for many pharmaceutical companies but requires them to donate all honoraria or consulting fees directly to charity so that he receives neither income nor a tax answer. No other study conflict of interest relevant to this case was reported. Address reprint requests to Dr.

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Nissen at the Department of Cardiovascular Medicine, Cleveland Clinic, Euclid Ave. Vamecq JLatruffe N. Medical significance of peroxisome proliferator-activated receptors. The clinical significance of PPAR gamma agonism. Curr Mol Med ;5: Center for Drug Evaulation and Research. Avandia rosiglitazone maleate tablets. Accessed May 18,at http: Complications of diabetes in the United States. Center employee training research paper Drug Evaluation and Research.

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Journal of Biopharmaceutical Statistics 17 Formosa, Nina Eikelis, David A. Barwood, Shane Nanayakkara, Neale D. Cohen, Andre La Gerche, Answers T. Joanna Tieu, Suzette Coat, William Hague, Philippa Middleton, Emily Shepherd. Cochrane Database of Systematic Reviews Tate Cutshall, Jennifer D. Annals of Medicine Ashwini Kumar, Sudhanshu Kumar Bharti, Awanish Kumar. What we have and what are we expecting?. De Sanctis, Gabriella Wojewodka, Daniel Houle, Shanon Cupri, Asmahan Abu-Arish, John W.

Hanrahan, Marian Hajduch, Elias Matouk, Danuta Radzioch. Journal of Molecular Medicine Elaine Nguyen, Craig I. Coleman, Suresh Nair, Erin R. Journal of Diabetes and its Complications. Suzanne V Arnold, Silvio E Inzucchi, Fengming Tang, Darren K McGuire, Sanjeev N Mehta, Thomas M Maddox, Abhinav Goyal, Laurence S Sperling, Daniel Einhorn, Keith D Wong, Kamlesh Khunti, Carolyn SP Lam, Mikhail Kosiborod.

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